B+
Bull case
25%
Probability
Target price
$73.50
Analysis reference price unavailable
Analysis 2026-02-27 · RankAlpha Sentiment AI
SYRE
Spyre TherapeuticsFNasdaq / Pharmaceuticals, Biotechnology & Life Sciences
Last Price
Quote time unavailable
Current thesis
Bull case: positive pivotal data and favourable regulatory progress push adoption expectations toward the high end of analyst targets, validating a premium multiple and supporting material upside [#SERP-1].
Posture
Defensive
Lead driver
Value
What changed
Value remains the lead driver in the composite, 7D delta -0.0.
What can break
Binary clinical readout failure or mixed efficacy
Momentum
49
Value
41
Sentiment
18
Setup hits (3d)
0 · Net Neutral
AI TargetsBase $54.29 · Bull $73.50 · Bear $40.00Analysis 2026-02-27; returns require an exact persisted reference.
Data freshness
Prices
Unavailable: Price unavailable
Fundamentals
As of 2026-08-17 • Vendor: Data Vendor v1
Scores
As of 2026-09-11 • Model: HYBRID_IC_RP
AI Memo
As of 2026-02-27 • Model: RankAlpha Sentiment AI
Investment thesisAs of 2026-09-11
Investment thesis
As of 2026-09-11
Grade is the composite factor band; factor scores use a 0–100 scale. Confidence describes evidence quality, not a probability of return. Score date: 2026-09-11. Definitions
Supporting evidence
What
Grade F · Defensive
Confidence Medium · Net Neutral
Target $121.67
Why
Momentum49 · Δ7d -10.3
Value41 · Δ7d -0.0
Sentiment18 · Δ7d -2.3
So what
Weak posture (Net Neutral). Prioritize risk control and patience.
Confirming evidence
- • Value remains the lead driver in the composite, 7D delta -0.0.
Contradictions & invalidation
- • Binary clinical readout failure or mixed efficacy
- • Competitive entrant with superior data
- • Bear case: failed or mixed readouts, regulatory delays, or commercialization setbacks depress expectations toward the analyst low and trigger downside pressure given current anchoring [#SERP-2].
Catalyst clock
2026-05-28
Near-term quarterly earnings & corporate update
Lead driver: Value · See fundamentals
Momentum
49
9% active weight
Current posture
7d trendSoftening
Δ7d
-10.3
Δ21d
-48.1
Value
41
28% active weight
Current posture
7d trendFlat
Δ7d
-0.0
Δ21d
+0.1
Sentiment
18
62% active weight
Current posture
7d trendSoftening
Δ7d
-2.3
Δ21d
+13.0
Why this grade
Composite grade F. Momentum 49.3 / Value 41.2 / Sentiment 17.8
Scenario snapshot
Scenario probability is memo-authored likelihood, not forecast certainty. Targets belong to the analysis dated 2026-02-27. Scenario method
Most likely
B
Base case
60%
Probability
Target price
$54.29
Analysis reference price unavailable
Analysis 2026-02-27 · RankAlpha Sentiment AI
B-
Bear case
15%
Probability
Target price
$40.00
Analysis reference price unavailable
Analysis 2026-02-27 · RankAlpha Sentiment AI
Fundamentals (TTM)As of 2026-08-17
Fundamentals (TTM)
As of 2026-08-17
Market Cap
$9.22B
Beta
3.17
Shares Out
88.17M
P/E (TTM) · Derived
-52.9
P/S (TTM)
-
P/FCF (TTM) · Derived
-38.18
Rev YoY
-100.0%
EPS YoY
-29.4%
Gross Margin
+39.5%
Op Margin
-
Net Debt
-$756.53M
Current Ratio
18.53
As of 2026-09-11 • Updated nightlySource: Internal modelMethods & Data