LIXT

BOCA RATON, Fla., May 14, 2026 (GLOBE NEWSWIRE) -- LIXTE Biotechnology Holdings, Inc. (“LIXTE” or the “Company”) (Nasdaq: LIXT), a clinical stage pharmaceutical and med-tech company focused on advancing cancer treatments, today announced it has filed its Quarterly Report on Form 10-Q with the U.S. Securities and Exchange Commission (“SEC”) for the first quarter ended March 31, 2026. The report is available on the Company’s website, www.lixte.com, and on the SEC’s website, www.sec.gov. “We are making progress in advancing our lead compound, LB-100, which has consistently shown synergy with today’s chemotherapy and immunotherapy approaches for the treatment of cancer,” said Geordan Pursglove, LIXTE’s Chairman and Chief Executive Officer. “Following a recent study confirming the favorable safety profile of LB-100 in combination with GSK’s dostarlimab, we have expanded our ovarian cancer trial and continue to enroll additional patients. “The continued growth of our recently acquired Liora Technologies Europe subsidiary (“Liora) further strengthens our ability to accelerate innovative cancer therapies, including the treatment of tumors using proton therapy through Liora’s LIGHT System,” added Pursglove. “We continue to evaluate opportunities to expand strategically and look forward to further growing our team through the pursuit of complementary oncology assets that enhance our pipeline and accelerate the development of new and effective treatments. I am proud of our team’s dedication to delivering meaningful innovation for patients, and believe that continued progress will drive improved outcomes and long-term value for our shareholders.” Recent Operational Highlights Advanced integration and strategic development initiatives at Liora Technologies Europe during the first quarter of 2026, supporting the continued expansion of the LIGHT System platform and strengthening the Company’s position in innovative proton therapy solutions. Sponsored inaugural Good Health: Mind, Body & Soul Summit, bringing together leaders in health, culture, science, and community to advance health equity for Black men and families. The Summit aligns with LIXTE’s commitment to advancing cancer care through LB-100, and its Liora research subsidiary. Presented favorable preliminary results for a clinical trial testing the combination of Lixte’s proprietary compound LB-100 in combination wi...

LOS ANGELES, CA - April 13, 2026 (NEWMEDIAWIRE) - LIXTE Biotechnology Holdings (NASDAQ: LIXT), a clinical-stage pharmaceutical company advancing cancer treatments, announced preliminary results from a clinical trial evaluating its proprietary compound LB-100 in combination with dostarlimab at the 2026 Society of Gynecologic Oncology conference in San Juan, Puerto Rico. Interim data from 20 evaluable patients showed a 40% disease control rate and encouraging survival trends with an acceptable safety profile, supporting continued enrollment of an expanded cohort as the company investigates the combination's potential to enhance immunotherapy response in ovarian clear cell carcinoma. To view the full press release, visit https://ibn.fm/alcex About LIXTE Biotechnology Holdings, Inc. LIXTE Biotechnology Holdings, Inc. is a clinical-stage pharmaceutical and med-tech company focused on new targets for cancer drug development and developing and commercializing cancer therapies. LIXTE has demonstrated that LB-100, its lead compound and first-in-class lead clinical PP2A inhibitor, is well-tolerated in cancer patients at doses associated with anti-cancer activity. Based on published preclinical data, LB-100 has the potential to significantly enhance chemotherapies and immunotherapies and improve outcomes for patients with cancer. It is part of a pioneering effort in an entirely new field of cancer biology - activation lethality - that is advancing a new treatment paradigm. LIXTE's novel approach is covered by a comprehensive patent portfolio, with proof-of-concept clinical trials currently in progress for Ovarian Clear Cell Carcinoma, Metastatic Colon Cancer and Advanced Soft Tissue Sarcoma. Additional information can be found atwww.lixte.com. Through LIXTE's wholly owned subsidiary,Liora Technologies Europe Ltd., the Companyalsoispioneeringthe development ofelectronically controlled proton therapy systems for treating tumors in various types of cancers. Liora's proprietary flagship technology, LiGHT System, is believed to provide significant advantages over currently available technologies for treating tumors with proton therapy. Additional information about Liora Technologies can be found atwww.lioratechnologies.com. Please see full terms of use and disclaimers on the InvestorBrandNetwork website applicable to all content provided by IBN, wherever published or re-pub...

-Trial Combines LIXTE’s LB-100 with Dostarlimab; Results Give Patients New Hope for a Challenging Disease with Limited Therapeutic Options- BOCA RATON, Fla., April 13, 2026 (GLOBE NEWSWIRE) -- LIXTE Biotechnology Holdings, Inc. (“LIXTE” or the “Company”) (Nasdaq: LIXT), a clinical stage pharmaceutical and med-tech company focused on advancing cancer treatments, today announced the presentation of preliminary results for a clinical trial testing the combination of Lixte’s proprietary compound LB100 in combination with Dostarlimab at the 2026 Conference of the Society of Gynecological Cancer, April 10-13, in San Juan, Puerto Rico. The annual conference brings together a diverse group of specialists, including gynecologic oncologists, radiation oncologists, nurses, researchers and others to share the latest scientific advancements. It features exhibitors from various medical device and pharmaceutical companies, showcasing cutting-edge products and services tailored for the gynecologic cancer care team. “The findings being presented provide new hope for patients with ovarian cancer, a disease that thus far has limited therapeutic options,” said Bas van der Baan, LIXTE’s Chief Scientific Officer. “LIXTE’s proprietary compound, LB-100, combined with GSK’s anti PD1 drug Dostarlimab, has shown an acceptable safety profile. All 21 planned participants in the trial have been enrolled, and 20 were evaluated for efficacy in this interim analysis. Based on those favorable results, an additional cohort of 21 patients with a higher exposure to LB-100 is in the process of enrolling.” Trial Results At a median follow-up length of 12 months (range 1.4-22), median OS has not been reached. However, OS probability was 0.84 (95%CI 0.64-0.94) at 6 months and 0.69 (95% CI 0.44-0.84) at 12 months. The Disease Control Rate was 40% (8/20, 95% CI 19.1-63.9%). The trial is based on the observation by the lead clinical investigator Amir Jazaeri MD, Professor of Gynecologic Oncology at The University of Texas MD Anderson Cancer Center, that a genetically acquired reduction in PP2A activity may increase responsiveness to immune checkpoint blockade (ICB) in Ovarian Clear Cell Carcinoma (OCCC), particularly in tumors harboring somatic PPP2R1A mutations resulting in loss of protein phosphatase 2A (PP2A) function. “We are learning more about the molecular features of ovarian clear-cell carcino...