JBIO

SAN FRANCISCO and VANCOUVER, British Columbia, May 29, 2026 (GLOBE NEWSWIRE) -- Jade Biosciences, Inc. (the “Company” or “Jade”) (Nasdaq: JBIO), a clinical-stage biotechnology company focused on developing best-in-class therapies for autoimmune diseases, today announced that it will host a conference call and webcast on Monday, June 1, 2026, at 8:00 a.m. ET to discuss results from the ongoing Phase 1 healthy volunteer study of JADE101. The data are expected to define the dosing strategy and further characterize JADE101’s clinical profile as a potentially differentiated, disease-modifying anti–A Proliferation-Inducing Ligand (APRIL) monoclonal antibody for the treatment of immunoglobulin A nephropathy (IgAN). Conference Call and Webcast Jade Biosciences will host a conference call and webcast on Monday, June 1, 2026, at 8:00 a.m. ET to discuss the JADE101 clinical data. Investors and the general public are invited to listen to the live webcast and may register on the “Events and Presentations” page of the company’s website at JadeBiosciences.com. To join the live conference call, participants must register here. Upon registering, participants will receive dial-in details and a unique PIN to access the call. A replay of the webcast will be available on the Jade website shortly after the call concludes. About IgA nephropathy (IgAN) IgAN is a chronic autoimmune kidney disease that affects approximately 169,000 people in the U.S. and is most often diagnosed in young adults. The disease is characterized by the deposition of pathogenic IgA-containing immune complexes in the kidneys. These deposits can lead to increased protein in the urine, also known as proteinuria, declining kidney function, and potentially end-stage kidney disease requiring dialysis or a transplant. IgAN often requires lifelong treatment to preserve kidney function and prevent progression to kidney failure. About JADE101 JADE101 is a fully human monoclonal antibody that selectively blocks APRIL with ultra-high binding affinity and is engineered for half-life extension. Preclinical studies demonstrated potent, sustained IgA suppression after a single dose in non-human primates, with a serum half-life of approximately 27 days. JADE101 was designed to avoid formation of high molecular weight immune complexes, with the goal of supporting predictable pharmacokinetics and reduced immunogenicity risk....

Interim biomarker-rich Phase 1 data for JADE101 to be featured in an oral session at the 63rd European Renal Association Congress Phase 2 trial of JADE101 in IgA nephropathy patients expected to begin in the second quarter of 2026; interim data expected in 2027 Phase 1 study of JADE201, a half-life extended afucosylated anti-BAFF-R antibody, expected to begin in the second quarter of 2026; interim data expected in 2027 Phase 1 clinical trial for JADE301 remains on track to begin in the first half of 2027 $311 million in cash, cash equivalents, and investments as of March 31, 2026 expected to provide runway into the first half of 2028 SAN FRANCISCO and VANCOUVER, British Columbia, May 07, 2026 (GLOBE NEWSWIRE) -- Jade Biosciences, Inc. (“Jade” or the “Company”) (Nasdaq: JBIO), a biotechnology company focused on developing best-in-class therapies for autoimmune diseases, today announced financial results for the first quarter ending March 31, 2026, and provided a corporate update. “With the upcoming initial biomarker-rich Phase 1 data for our lead program, JADE101, and an additional program expected to enter the clinic this quarter, we are transitioning into a new phase of focused clinical execution,” said Tom Frohlich, Chief Executive Officer of Jade Biosciences. “We believe these milestones position us to generate meaningful clinical insights across our portfolio over the coming quarters, while continuing to rapidly advance our pipeline of potentially best-in-class therapies for autoimmune diseases.” Pipeline and Corporate Updates JADE101: potentially best-in-class selective anti-APRIL monoclonal antibody for IgA nephropathy (IgAN) Biomarker-rich interim data from the Phase 1 healthy volunteer study of JADE101 to be presented in an oral session at the 63rd European Renal Association (ERA) Congress. These data are expected to define the dose and dosing interval for subsequent JADE101 IgAN patient studies and further characterize JADE101’s profile. Following review of the Phase 1 data, Jade expects to evaluate potential opportunities to accelerate the clinical development of JADE101. The company expects to initiate a Phase 2 clinical trial evaluating JADE101 in patients with IgAN in the second quarter of 2026; interim data are expected in 2027. A Trial-in-Progress presentation will be delivered during an oral session at the 2026 ERA Congress. JADE201: potentia...

JADE101 Phase 1 healthy volunteer interim data expected in the second quarter of 2026; Phase 2 clinical trial in patients with IgA nephropathy expected to begin mid-2026 with preliminary data anticipated in 2027 JADE201, a half-life extended afucosylated anti-BAFF receptor antibody, expected to advance into first-in-human clinical trial in rheumatoid arthritis patients in the second quarter of 2026; interim data anticipated in 2027 Third development candidate, JADE301, nominated; Phase 1 clinical trial expected to commence in the first half of 2027 $336 million of cash, cash equivalents, and investments as of December 31st, 2025 expected to provide runway into the first half of 2028 SAN FRANCISCO and VANCOUVER, British Columbia, March 06, 2026 (GLOBE NEWSWIRE) -- Jade Biosciences, Inc. (“Jade” or the “Company”) (Nasdaq: JBIO), a biotechnology company focused on developing best-in-class therapies for autoimmune diseases, today announced financial results for the fourth quarter and full year ending December 31, 2025, and provided a corporate update. Tom Frohlich, Chief Executive Officer of Jade Biosciences, commented: “We closed 2025 with strong momentum, having initiated the JADE101 Phase 1 healthy volunteer study, continued to advance JADE201 toward the clinic, and further strengthened our team and balance sheet. As we look ahead, our focus is on delivering interim, biomarker-rich Phase 1 data for JADE101, initiating the Phase 2 clinical trial in IgA nephropathy, and starting first-in-human dosing for the Phase 1 clinical trial of JADE201. With multiple clinical milestones approaching and cash runway expected to extend into the first half of 2028, we are well positioned to execute on our near-term priorities while continuing to build a differentiated pipeline with the goal of delivering best-in-class, disease-modifying autoimmune therapies to patients.” Pipeline and Corporate Updates JADE101: potentially best-in-class selective anti-APRIL monoclonal antibody for IgA nephropathy (IgAN) Phase 1 biomarker-rich interim results from the ongoing healthy volunteer study are expected in the second quarter of 2026 and are anticipated to define dose and dose interval selection for IgAN patient studies. Jade expects to evaluate the Phase 1 clinical data and explore opportunities to accelerate the development of JADE101. Jade expects to initiate a Phase 2 clinical trial...

Presented favorable preclinical safety data for JADE101 and a translational analysis of APRIL mediated biomarker responses at the American Society of Nephrology Kidney Week 2025, reinforcing its potential as a best-in-class selective anti-APRIL monoclonal antibody for IgA nephropathy Initiated Phase 1 healthy volunteer study of JADE101; interim, biomarker-rich data expected in the first half of 2026 are anticipated to define dose and dose interval selection for patient trials Unveiled JADE201, a potentially best-in-class, half-life extended, afucosylated anti-BAFF receptor monoclonal antibody; first-in-human trial in rheumatoid arthritis expected to begin in the first half of 2026 with potential opportunity across multiple autoimmune diseases validated by BAFF-R biology Completed $135 million private placement, extending cash runway into the first half of 2028 SAN FRANCISCO and VANCOUVER, British Columbia, Nov. 13, 2025 (GLOBE NEWSWIRE) -- Jade Biosciences, Inc. (“Jade”) (Nasdaq: JBIO), a biotechnology company focused on developing best-in-class therapies for autoimmune diseases, today announced financial results for the quarter ending September 30, 2025, and provided a corporate update. “The third quarter marked meaningful progress toward our mission of delivering potentially best-in-class therapies for autoimmune diseases,” said Tom Frohlich, Chief Executive Officer of Jade Biosciences. “At the recent ASN Kidney Week, we presented preclinical safety and translational data that support JADE101’s potential to be a best-in-class, selective anti-APRIL therapy and provide further confidence that biomarker data from our ongoing Phase 1 healthy volunteer trial will define the dosing strategy for IgAN patient studies. We also introduced our second development candidate, JADE201, which builds on validated BAFF-R biology to potentially address a broad range of autoimmune diseases, and completed a $135 million private financing. With these achievements, we are well positioned to execute on multiple clinical milestones and bring further innovation in autoimmune disease treatment.” Pipeline and Corporate Updates JADE101: potentially best-in-class selective anti-APRIL monoclonal antibody for IgA nephropathy (IgAN) Presented two posters at the American Society of Nephrology (ASN) Kidney Week 2025. JADE101 is an ultra-high affinity, half-life-extended fully human monoclon...

Presented preclinical data for JADE101 at the 62nd European Renal Association Congress, highlighting its potential as a best-in-class anti-APRIL monoclonal antibody for IgA nephropathy Phase 1 healthy-volunteer study of JADE101 expected to begin in the third quarter of 2025, with interim, biomarker-rich data anticipated in the first half of 2026 $220.9 million cash and cash equivalents as of June 30, 2025 supports cash runway through 2027, including multiple clinical inflection points SAN FRANCISCO and VANCOUVER, British Columbia, Aug. 13, 2025 (GLOBE NEWSWIRE) -- Jade Biosciences, Inc. (“Jade”) (Nasdaq: JBIO), a biotechnology company focused on developing best-in-class therapies for autoimmune diseases, today announced financial results for the quarter ending June 30, 2025, and provided a corporate update. “We’ve had a productive second quarter, in which we closed our reverse merger and significant financing, and continued to advance a pipeline aimed at delivering potentially best-in-class therapies that treat systemic and organ-specific autoimmune diseases,” said Tom Frohlich, Chief Executive Officer of Jade. “We recently presented compelling preclinical data on JADE101, which we believe support its potential to be a best-in-class disease-modifying therapy for IgA nephropathy. Additionally, recently announced clinical data from other programs further reinforce our belief that the anti-APRIL class will be the foundational therapy for this disease. We are excited to transition into a clinical-stage company in the coming months, and believe we are uniquely positioned to shape the treatment landscape for IgAN and other autoimmune diseases.” Pipeline and Corporate Updates JADE101: potentially best-in-class anti-APRIL monoclonal antibody for IgA nephropathy (IgAN) Presented preclinical data for JADE101 at the 62nd European Renal Association Congress. JADE101 is an ultra-high affinity, half-life-extended fully-human monoclonal antibody that has the potential for best-in-class activity with convenient patient dosing. Key findings reported included: JADE101 showed ultra-high APRIL binding affinity (~50 femtomolar KD, >750-fold higher than sibeprenlimab), potent and complete inhibition of APRIL signaling in vitro, and deep, sustained IgA suppression, with an extended half-life of approximately 27 days, after a single 30 mg/kg intravenous dose in non-human primates (...

Completed reverse merger and commenced trading on Nasdaq as JBIO Closed financing, raising approximately $300 million to date, providing cash runway through 2027 Lead candidate JADE101 expected to enter the clinic in second half of 2025, with interim biomarker-rich data expected in first half of 2026 SAN FRANCISCO and VANCOUVER, British Columbia, May 14, 2025 (GLOBE NEWSWIRE) -- Jade Biosciences, Inc. (“Jade”) (Nasdaq: JBIO), a biotechnology company focused on developing best-in-class therapies for autoimmune diseases, today announced financial results for the quarter ending March 31, 2025, and provided a corporate update. “The start to 2025 marked a defining period for Jade Biosciences as we successfully completed our reverse merger, commenced trading as JBIO on Nasdaq, and closed a significant private financing led by a premier syndicate of healthcare investors,” said Tom Frohlich, Chief Executive Officer of Jade. “With a strong balance sheet, we are well-positioned to advance our pipeline of potentially best-in-class therapies for autoimmune diseases. We’re especially excited to become a clinical-stage company later this year, with JADE101 on track to begin first-in-human studies in the second half of 2025. This represents a meaningful step toward delivering differentiated treatment options for patients living with chronic and underserved autoimmune conditions.” Corporate and Pipeline Updates Corporate Completed the previously announced reverse merger with Aerovate Therapeutics, Inc., concurrently closed a private placement and began trading on Nasdaq under the ticker symbol JBIO. JADE101: potentially best-in-class anti-APRIL monoclonal antibody for IgAN First-in-human clinical trial anticipated to begin in the second half of 2025 with interim data expected in the first half of 2026. Anti-APRIL mechanism of action provides biomarker-rich data in healthy volunteers that is expected to be predictive of clinical efficacy and will define the dose and schedule designed to fully suppress APRIL throughout the dosing interval in IgAN patients. JADE201: a development candidate from the JADE-002 antibody discovery program Nominated a development candidate from the JADE-002 program, named JADE201. First Quarter 2025 Financial Results Cash Position: As of March 31, 2025, Jade had available cash and cash equivalents of $49.9 million. Net cash used in operating activit...