B+
Bull case
25%
Probability
Target price
$330.00
Analysis reference price unavailable
Analysis 2026-08-08 · RankAlpha Sentiment Codex
ALNY
AlnylamCNasdaq / Pharmaceuticals, Biotechnology & Life Sciences
Last Price
Quote time unavailable
Current thesis
AMVUTTRA demand and TTR franchise growth remain powerful, with quarterly TTR revenue above $1 billion, expanding ATTR-CM opportunity, a China commercialization option, and a dated ALN-HTT02 clinical readout. [#SEC-8K-2026-07-30]
Posture
Mixed
Lead driver
Sentiment
What changed
Sentiment remains the lead driver in the composite, 7D delta -0.8.
What can break
ALN-HTT02 clinical results, other pipeline readouts, and regulatory outcomes could disappoint or be delayed.
Momentum
15
Value
61
Sentiment
62
Setup hits (3d)
0 · Net Neutral
AI TargetsBase $255.00 · Bull $330.00 · Bear $175.00Analysis 2026-08-08; returns require an exact persisted reference.
Data freshness
Prices
Unavailable: Price unavailable
Fundamentals
As of 2026-08-17 • Vendor: Data Vendor v1
Scores
As of 2026-09-09 • Model: HYBRID_IC_RP
AI Memo
As of 2026-08-08 • Model: RankAlpha Sentiment Codex
Investment thesisAs of 2026-09-09
Investment thesis
As of 2026-09-09
Grade is the composite factor band; factor scores use a 0–100 scale. Confidence describes evidence quality, not a probability of return. Score date: 2026-09-09. Definitions
Supporting evidence
What
Grade C · Mixed
Confidence Medium · Net Neutral
Target $374.25
Why
Momentum15 · Δ7d +10.5
Value61 · Δ7d -0.0
Sentiment62 · Δ7d -0.8
So what
Balanced signals (Net Neutral). Wait for confirmation before sizing up.
Confirming evidence
- • Sentiment remains the lead driver in the composite, 7D delta -0.8.
Contradictions & invalidation
- • ALN-HTT02 clinical results, other pipeline readouts, and regulatory outcomes could disappoint or be delayed.
- • AMVUTTRA China commercialization is contingent on marketing authorization, with timing unavailable.
- • The guidance reduction signals a slower ATTR-CM volume ramp than previously expected.
Catalyst clock
2026-10-23
ALN-HTT02 Phase 1 results at EHDN
Lead driver: Sentiment · See AI snapshot
Momentum
15
9% active weight
Current posture
7d trendImproving
Δ7d
+10.5
Δ21d
+11.3
Value
61
28% active weight
Current posture
7d trendFlat
Δ7d
-0.0
Δ21d
+1.7
Sentiment
62
62% active weight
Current posture
7d trendFlat
Δ7d
-0.8
Δ21d
-15.2
Why this grade
Composite grade C. Momentum 15.3 / Value 61.0 / Sentiment 61.5
Scenario snapshot
Scenario probability is memo-authored likelihood, not forecast certainty. Targets belong to the analysis dated 2026-08-08. Scenario method
Most likely
B
Base case
50%
Probability
Target price
$255.00
Analysis reference price unavailable
Analysis 2026-08-08 · RankAlpha Sentiment Codex
B-
Bear case
25%
Probability
Target price
$175.00
Analysis reference price unavailable
Analysis 2026-08-08 · RankAlpha Sentiment Codex
Fundamentals (TTM)As of 2026-08-17
Fundamentals (TTM)
As of 2026-08-17
Market Cap
$30.05B
Beta
0.35
Shares Out
133.81M
P/E (TTM)
1738.9
P/S (TTM)
16.37
P/FCF (TTM)
237.43
Rev YoY
+66.9%
EPS YoY
-318.3%
Gross Margin
+79.7%
Op Margin
+20.8%
Net Debt
$60.31M
Current Ratio
3.05
As of 2026-09-09 • Updated nightlySource: Internal modelMethods & Data