B+
Bull case
15%
Probability
Target price
$15.00
Analysis reference price unavailable
Analysis 2026-09-03 · RankAlpha Sentiment Codex
SION
Sionna TherapeuticsCNasdaq / Pharmaceuticals, Biotechnology & Life Sciences
Last Price
Quote time unavailable
Current thesis
The sharp reset leaves substantial upside if SION-451 produces credible clinical data or a strategic path forward; cash runway into 2028 preserves optionality. [#SEC-8K-2026-08-06]
Posture
Mixed
Lead driver
Sentiment
What changed
Sentiment remains the lead driver in the composite, 7D delta +6.9.
What can break
Clinical-stage pipeline concentration creates high binary trial and regulatory risk.
Momentum
1
Value
41
Sentiment
68
Setup hits (3d)
0 · Net Neutral
AI TargetsBase $6.25 · Bull $15.00 · Bear $2.50Analysis 2026-09-03; returns require an exact persisted reference.
Data freshness
Prices
Unavailable: Price unavailable
Fundamentals
As of 2026-08-17 • Vendor: Data Vendor v1
Scores
As of 2026-09-18 • Model: HYBRID_IC_RP
AI Memo
As of 2026-09-03 • Model: RankAlpha Sentiment Codex
Investment thesisAs of 2026-09-18
Investment thesis
As of 2026-09-18
Grade is the composite factor band; factor scores use a 0–100 scale. Confidence describes evidence quality, not a probability of return. Score date: 2026-09-18. Definitions
Supporting evidence
What
Grade C · Mixed
Confidence Medium · Net Neutral
Target $21.57
Why
Momentum1 · Δ7d +0.1
Value41 · Δ7d 0.0
Sentiment68 · Δ7d +6.9
So what
Balanced signals (Net Neutral). Wait for confirmation before sizing up.
Confirming evidence
- • Sentiment remains the lead driver in the composite, 7D delta +6.9.
Contradictions & invalidation
- • Clinical-stage pipeline concentration creates high binary trial and regulatory risk.
- • Low coverage, loose peers, and unavailable analyst revision data reduce confidence in price targets.
- • SION-719 is no longer advancing as an add-on to standard of care, while SION-451's next steps remain uncertain.
Catalyst clock
2026-12-02
SION-451 dual-combination program update
Lead driver: Sentiment · See AI snapshot
Momentum
1
9% active weight
Current posture
7d trendFlat
Δ7d
+0.1
Δ21d
+0.1
Value
41
28% active weight
Current posture
7d trendFlat
Δ7d
0.0
Δ21d
-0.0
Sentiment
68
62% active weight
Current posture
7d trendImproving
Δ7d
+6.9
Δ21d
-52.8
Why this grade
Composite grade C. Momentum 1.2 / Value 41.2 / Sentiment 68.2
Scenario snapshot
Scenario probability is memo-authored likelihood, not forecast certainty. Targets belong to the analysis dated 2026-09-03. Scenario method
Most likely
B
Base case
50%
Probability
Target price
$6.25
Analysis reference price unavailable
Analysis 2026-09-03 · RankAlpha Sentiment Codex
B-
Bear case
35%
Probability
Target price
$2.50
Analysis reference price unavailable
Analysis 2026-09-03 · RankAlpha Sentiment Codex
Fundamentals (TTM)As of 2026-08-17
Fundamentals (TTM)
As of 2026-08-17
Market Cap
$267.2M
Beta
-
Shares Out
45.21M
P/E (TTM) · Derived
-3.5
P/S (TTM)
-
P/FCF (TTM) · Derived
-3.48
Rev YoY
-
EPS YoY
+61.7%
Gross Margin
-
Op Margin
-
Net Debt
-$227.21M
Current Ratio
20.05
As of 2026-09-18 • Updated nightlySource: Internal modelMethods & Data