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IONS

IonisB
Nasdaq / Pharmaceuticals, Biotechnology & Life Sciences
Last Price
Quote time unavailable
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Current thesis
The selloff may over-discount a partnered-program failure if TRYNGOLZA gains traction and the wholly owned neurology portfolio executes. Ionis had $2.1 billion of cash and short-term investments at June 30 and remained on track for 2026 financial guidance at the July update.
Posture
Constructive
Lead driver
Sentiment
What changed
Next scheduled catalyst: earnings 2026-10-27.
What can break
Full Lp(a)HORIZON data could deepen negative read-through across Ionis's cardiometabolic pipeline or reveal limited salvageable subgroups.
Momentum
15
Value
41
Sentiment
82
Setup hits (3d)
0 · Net Neutral
AI TargetsBase $55.00 · Bull $70.00 · Bear $38.00Analysis 2026-09-15; returns require an exact persisted reference.
Earnings
2026-10-27
Data freshness
Prices
Unavailable: Price unavailable
Fundamentals
As of 2026-10-23 • Vendor: Data Vendor v1
Scores
As of 2026-10-23 • Model: HYBRID_IC_RP
AI Memo
As of 2026-09-15 • Model: RankAlpha Sentiment Codex
Investment thesis
As of 2026-10-23

Grade is the composite factor band; factor scores use a 0–100 scale. Confidence describes evidence quality, not a probability of return. Score date: 2026-10-23. Definitions

Supporting evidence
What
Grade B · Constructive
Confidence Medium · Net Neutral
Target $84.14
Why
Momentum15 · Δ7d +7.9
Value41 · Δ7d -0.1
Sentiment82 · Δ7d +1.0
So what
Strength-led posture (Net Neutral). Favor watchlist adds and disciplined entries.

Confirming evidence

  • • Next scheduled catalyst: earnings 2026-10-27.
  • • Sentiment remains the lead driver in the composite, 7D delta +1.0.

Contradictions & invalidation

  • • Full Lp(a)HORIZON data could deepen negative read-through across Ionis's cardiometabolic pipeline or reveal limited salvageable subgroups.
  • • Pelacarsen failed to reduce the primary composite cardiovascular endpoint, despite substantial Lp(a) lowering. [#8-K-2026-09-04]
  • • Lp(a)HORIZON failed its primary cardiovascular endpoint, removing an important large-market source of optionality and raising platform read-through questions.

Catalyst clock

2026-10-27

Lp(a)HORIZON full-data presentation

Lead driver: Sentiment · See AI snapshot
Momentum
15
8% active weight
Current posture
7d trendImproving
Δ7d
+7.9
Δ21d
+11.9
Value
41
47% active weight
Current posture
7d trendFlat
Δ7d
-0.1
Δ21d
-0.4
Sentiment
82
45% active weight
Current posture
7d trendSoftening
Δ7d
+1.0
Δ21d
-11.0
Why this grade

Composite grade B. Momentum 14.7 / Value 40.6 / Sentiment 82.0

Scenario snapshot

Scenario probability is memo-authored likelihood, not forecast certainty. Targets belong to the analysis dated 2026-09-15. Scenario method

B+
Bull case
25%
Probability
Target price
$70.00
Analysis reference price unavailable
Analysis 2026-09-15 · RankAlpha Sentiment Codex
Most likely
B
Base case
45%
Probability
Target price
$55.00
Analysis reference price unavailable
Analysis 2026-09-15 · RankAlpha Sentiment Codex
B-
Bear case
30%
Probability
Target price
$38.00
Analysis reference price unavailable
Analysis 2026-09-15 · RankAlpha Sentiment Codex
Fundamentals (TTM)
As of 2026-10-23
Market Cap
$7.13B
Beta
0.29
Shares Out
166.18M
P/E (TTM) · Derived
-18.0
P/S (TTM)
13.15
P/FCF (TTM) · Derived
-12.42
Rev YoY
-40.7%
EPS YoY
-202.3%
Gross Margin
+95.7%
Op Margin
-68.1%
Net Debt
-$63.11M
Current Ratio
7.89
As of 2026-10-23 • Updated nightlySource: Internal modelMethods & Data