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IONS

IonisA
Nasdaq / Pharmaceuticals, Biotechnology & Life Sciences
Last Price
Quote time unavailable
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Current thesis
Commercial momentum in Tryngolza and Dawnzera, a substantial cash and short-term investment balance of $2.1 billion, and multiple second-half pipeline milestones could support a rerating. The packet's median analyst target is $89.60 versus the $54.49 anchor price, but target coverage breadth is unavailable.
Posture
Constructive
Lead driver
Sentiment
What changed
1 setup hits (3d) with net bearish as of 2026-09-09.
What can break
Clinical and regulatory outcomes for zilganersen and pelacarsen could materially change the thesis.
Momentum
17
Value
41
Sentiment
91
Setup hits (3d)
1 · Net Bearish
AI TargetsBase $68.00 · Bull $95.00 · Bear $42.00Analysis 2026-08-04; returns require an exact persisted reference.
Data freshness
Prices
Unavailable: Price unavailable
Fundamentals
As of 2026-08-17 • Vendor: Data Vendor v1
Scores
As of 2026-09-09 • Model: HYBRID_IC_RP
AI Memo
As of 2026-08-04 • Model: RankAlpha Sentiment Codex
Investment thesis
As of 2026-09-09

Grade is the composite factor band; factor scores use a 0–100 scale. Confidence describes evidence quality, not a probability of return. Score date: 2026-09-09. Definitions

Supporting evidence
What
Grade A · Constructive
Confidence Medium · Net Bearish
Target $84.24
Why
Momentum17 · Δ7d +6.1
Value41 · Δ7d 0.0
Sentiment91 · Δ7d +15.3
So what
Strength-led posture (Net Bearish). Favor watchlist adds and disciplined entries.

Confirming evidence

  • • 1 setup hits (3d) with net bearish as of 2026-09-09.
  • • Sentiment remains the lead driver in the composite, 7D delta +15.3.

Contradictions & invalidation

  • • Clinical and regulatory outcomes for zilganersen and pelacarsen could materially change the thesis.
  • • Operating expenses and commercialization spending may pressure cash flow before product revenue scales.
  • • The investment case remains binary: zilganersen approval, pelacarsen outcomes, and launch execution could disappoint.

Catalyst clock

2026-07-29

Q2 beat with reaffirmed 2026 outlook

Lead driver: Sentiment · See AI snapshot
Momentum
17
9% active weight
Current posture
7d trendImproving
Δ7d
+6.1
Δ21d
+11.4
Value
41
28% active weight
Current posture
7d trendFlat
Δ7d
0.0
Δ21d
+0.1
Sentiment
91
62% active weight
Current posture
7d trendImproving
Δ7d
+15.3
Δ21d
+9.4
Why this grade

Composite grade A. Momentum 17.4 / Value 41.2 / Sentiment 90.5

Scenario snapshot

Scenario probability is memo-authored likelihood, not forecast certainty. Targets belong to the analysis dated 2026-08-04. Scenario method

B+
Bull case
25%
Probability
Target price
$95.00
Analysis reference price unavailable
Analysis 2026-08-04 · RankAlpha Sentiment Codex
Most likely
B
Base case
50%
Probability
Target price
$68.00
Analysis reference price unavailable
Analysis 2026-08-04 · RankAlpha Sentiment Codex
B-
Bear case
25%
Probability
Target price
$42.00
Analysis reference price unavailable
Analysis 2026-08-04 · RankAlpha Sentiment Codex
Fundamentals (TTM)
As of 2026-08-17
Market Cap
$9.74B
Beta
0.29
Shares Out
166.18M
P/E (TTM) · Derived
-24.6
P/S (TTM)
13.15
P/FCF (TTM) · Derived
-16.96
Rev YoY
-40.7%
EPS YoY
-202.3%
Gross Margin
+95.7%
Op Margin
-68.1%
Net Debt
-$63.11M
Current Ratio
7.89
As of 2026-09-09 • Updated nightlySource: Internal modelMethods & Data